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-synuclein, which happens to be a main component of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, and that is an E3 ubiquitin ligase and results in endoplasmic reticulum (ER) stress, suggest that dysfunction of your intracellular proteinase devices, for instance ubiquitin-proteasome technique or lysosomal technique, which elimina